Plant Systems Biology and Evolution
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Welcome to the Mutwil Lab!
​The Mutwil lab is located within the School of Biological Sciences at Nanyang Technological University, Singapore.
Our group aims to uncover the function and evolution of genes, stress resilience mechanisms, and specialized metabolic biosynthetic pathways in algae and land plants using large-scale, comparative experimental, and computational approaches. Our work focuses on four interconnected research pillars: Evolution, Stress Resilience, Specialized Metabolism, and Tools & Databases. By analyzing genomic, expression, and protein-protein interaction data for hundreds of plant species, the research will expand knowledge of gene function and the evolution of the plant kingdom, with applications in engineering stress-resilient crops with higher nutritional values. The team's findings will be made accessible through online databases, which will offer invaluable resources to researchers studying gene function, evolution, and stress resilience in plants.

End of 2019!

6/12/2019

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It has been a while since the last update and a lot of good things happened. 

1) We had a pleasure to host four fantastic Final Year Project (FYP) students for three months.  Ying Kiat (nr. 1 from the left) and Vernice (3) were supervised by Dr. Devendra Shivhare (2) and Dr. Zhu Xinyi (SCELSE, not shown), and have identified many plant extracts that inhibit planktonic and biofilm growth of Pseudomonas ​aeruginosa and Staphylococcus aureus. Mun Yi (4) and Veronique (6) were supervised by Qiao Wen Tan (5) to study stress memory and cross-acclimation to multiple abiotic stresses in Arabidopsis thaliana​. 
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2) The group expanded. Dr. Irene Julca and Dr. Riccardo Delli-Ponti joined to work on the Hedyotis genome project and on an online database capturing expression of biosynthetic pathways, respectively.
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3) We finished coordinating the first run of Computational Thinking course (BS1009). Now ~230 students are (theoretically) able to write useful scripts in Python. It was a great experience and we look forward to do it again next year. ​
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4) We got some papers out this year and produced two comparative transcriptomic databases: malaria.tools allows comparative genomic and transcriptomic analyses for Plasmodium species, while diurnal.tools can analyse diurnal gene expression in 17 members of Archaeplastida, including  algae and land plants. Diurnal.tools lands in research highlights in Plant Cell and Physiology. 
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5) Devendra, Irene and Marek attended a bryophyte workshop in Melbourne in December. It was good to catch up on Marchantia research and hang out with Prof. Dr. Staffan Persson! 
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    Contact

    Assoc. Prof. Marek Mutwil
    School of Biological Sciences
    Nanyang Technological University
    60 Nanyang Drive, 02s-88h
    ​Singapore 637551
    ​Email: mutwil[at]ntu.edu.sg

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